A/Prof Ashley Mansell
VIIN Executive Committee Member
Laboratory Head
Centre for Innate Immunity and Infectious Diseases
Hudson Institute of Medical Research
ashley.mansell@monash.edu
Research Activities
Pattern Recognition Receptors based research investigating:- The Toll-like receptor (TLRs), RIG-like Helicase (RLHs) and NOD-like receptors (NLRs)
- Signal transduction pathways initiated upon recognition of both pathogen and endogenous TLR ligands
- Structure/Function analysis of TLR signaling mediators
- Negative regulation of these pathways to prevent chronic inflammation
- Pathogen immunomodulation of these pathways/receptors
Techniques/Expertise
activation of NF-kB and IFNγ by various meanscell biology
TLR screening
Viral infections
TLR expressing cell lines
TLR/PRR/Signaling pathway
immortalized gene-deficient BMMs
Inflammasome Imaging
Collaborations
Luke O'Neill, Trinity College DublinKatherine Fitzgerald, University of Massachusetts
Eicke Latz, University of Bonn
Bostjan Kobe, University of Queensland
Prof Phillip Nagley
A/Prof Richard Ferrero
Julie McAuley (Peter Doherty Institute)
Andrew Bowie, Trinity College Dublin
Nick Gay, Cambridge University
Douglas Golebock, Universitiy of Massachusetts
Prof Brendan Jenkins
Michelle Baker, CSIRO, AAHL
Dr Michelle Tate
Disease Models
Septic ShockViral Infection
Inflammasome
Influenza A virus
E. coli
Genetically Modified Organisms
Mal-/-, Mal D96NMul1 KO
ASC-/-
NLRP3-/-
Websites
www.monashinstitute.org/centres/ciiid/toll-like-receptor-signalling.htmlhudson.org.au/pattern-recognition-receptors-and-inflammation/
www.iiasi.org
Other Lab Members
Dr Jen Dowling, Post-Doctoral FellowMs Anita Pinar, PhD Student
Mr James Ong, PhD Student
